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How many miles per gallon does a 2022 Lexus RX 450h hybrid get?

The 2022 Lexus RX 450h hybrid typically delivers around 30 miles per gallon combined, with EPA estimates showing approximately 31 mpg city and 28 mpg highway for front‑wheel‑drive (FWD) models and a touch lower overall for all‑wheel‑drive (AWD) versions.


EPA estimates and drivetrain differences


EPA fuel economy figures vary by drivetrain. The following official estimates reflect the two available configurations for the 2022 RX 450h.



  • RX 450h FWD: 31 mpg city / 28 mpg highway / 30 mpg combined.

  • RX 450h AWD: 29 mpg city / 28 mpg highway / 29 mpg combined.


These numbers provide a baseline for budgeting fuel costs and comparing trims. Actual mileage may vary based on driving conditions, climate control use, and other factors.


How the hybrid system contributes to efficiency


The RX 450h pairs a 3.5-liter V6 with electric motors to optimize power delivery and fuel use. In city driving, electric assist and regenerative braking help boost efficiency, while highway cruising emphasizes steady engine operation. The balance between electric and gasoline power is managed automatically, aiming to maximize mpg without sacrificing performance.


Real-world performance and factors that influence mpg


In everyday driving, the RX 450h’s mileage tends to cluster near the EPA estimates, but several conditions can push the real-world figure higher or lower.



  • Driving style: smoother acceleration and slower speeds generally improve mpg.

  • Terrain and speed: hilly or congested urban driving lowers mpg relative to long highway trips.

  • Drivetrain: the AWD version typically records a small mpg penalty versus the FWD model due to drivetrain losses.

  • Climate control and battery temperature: heating or cooling the cabin and keeping the hybrid battery at optimal temperature can affect efficiency.

  • Tire condition and tire type: proper inflation and rolling resistance influence fuel economy.


Most owners report mpg that stays within a few miles per gallon of the EPA figures, with real-world results highly dependent on how and where the vehicle is driven.


Summary


The 2022 Lexus RX 450h hybrid offers an EPA-estimated 30 mpg combined on average, with 31/28/30 mpg (city/highway/combined) for FWD and 29/28/29 mpg for AWD. Real-world mileage varies based on driving habits, route, and vehicle condition, but the RX 450h generally delivers solid efficiency for a midsize SUV with a hybrid powertrain. If you’re evaluating fuel costs for a purchase, use these figures as a baseline and adjust for your typical driving patterns.

What is the difference between Lexus 450h and 450h+?


2025 Lexus RX 450h is a 5-seat SUV that offers 838 L (29.6 ft³) of trunk space behind the rear seats and that opens up to 1308 L (46.2 ft³) with the rear seats folded down. The 5-seat SUV 2025 Lexus NX 450h+ has a 643 L (22.7 ft³) trunk and up to 1328 L (46.9 ft³) with the rear seats stowed.



How many miles per gallon does the 2022 Lexus RX 450h get?


The 2022 Lexus RX 450h gets an EPA-estimated 31 mpg city / 28 mpg highway / 30 mpg combined. The longer wheelbase RX 450hL model has a slightly lower city rating of 29 mpg, while the highway rating remains the same at 28 mpg. Your actual mileage will vary depending on driving conditions, your vehicle's condition, and how you drive. 
This video provides a detailed review of the 2022 Lexus RX 450h: 59sLexus South PointeYouTube · Mar 27, 2025

  • Standard RX 450h: 31 mpg city / 28 mpg highway / 30 mpg combined 
  • RX 450hL (Long Wheelbase): 29 mpg city / 28 mpg highway 
  • Actual mileage: Varies based on factors like driving habits, vehicle condition, and where you drive. 



How many miles per gallon does the RX450h hybrid get?


The Lexus RX 450h gets an EPA-estimated 31 mpg in the city and 28 mpg on the highway, for a combined average of around 30 mpg. These figures can vary based on factors like driving conditions, vehicle maintenance, and driving habits. Some longer-wheelbase versions (RX 450hL) get slightly lower city mileage, around 29 mpg.
 
You can watch this video to learn about the 2022 Lexus RX 450h's fuel economy and fill-up costs: 59sFuel EconomyYouTube · Aug 7, 2022

  • City: 31 mpg
  • Highway: 28 mpg
  • Combined: Approximately 30 mpg
  • Note: The larger RX 450hL model has slightly lower city mileage (29 mpg). 

This video demonstrates the real-world highway fuel economy of the 2021 Lexus RX 450h: 1mDaily MotorYouTube · Jan 13, 2021



What are the common problems with the 2022 RX 450h?


Premature pad/rotor wear, pulsation or vibration, antilock system, parking brake, master cylinder, calipers, squeaking, brake failure, regenerative braking.


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Kevin Bennett

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Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.