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How many miles per gallon does a 2022 Chevy 2500 6.6 diesel get?

In general, expect roughly 11–15 miles per gallon combined, with highway numbers often in the mid- to high-teens for two-wheel-drive models and lower for four-wheel-drive or dual-rear-wheel setups. Actual mileage depends on configuration, payload, and driving conditions.


Understanding EPA estimates by common configurations


Common drivetrain and cab/bed setups


The EPA publishes separate fuel economy estimates for each configuration. Below are representative ranges for the Duramax-powered 2500HD across typical setups. Actual figures vary by year, trim, and testing conditions.



  • 2WD Crew Cab with standard bed (SRW/DRW): Combined roughly 13–15 mpg; city around 11–13 mpg; highway around 17–19 mpg.

  • 4WD Crew Cab with standard bed: Combined roughly 12–14 mpg; city around 10–12 mpg; highway around 16–18 mpg.

  • 4WD Crew Cab with dual rear wheels (DRW): Combined roughly 11–13 mpg; city around 9–11 mpg; highway around 15–17 mpg.


These ranges reflect how drivetrain and wheel configuration influence efficiency. Real-world mileage will vary with payload, towing, terrain, and driving style.


What these numbers mean for towing and daily driving


Diesel trucks prioritize torque and pulling power, so fuel economy can drop significantly when towing heavy loads or navigating hilly terrain. For everyday driving without heavy towing, 2WD configurations tend to approach the highway estimates more closely.


Note: Exact EPA figures depend on the precise build. For the most accurate numbers, consult the official EPA window sticker for your exact configuration.


Other factors that influence mpg


Beyond drivetrain: what else matters


Several practical factors influence real-world fuel economy beyond the base EPA ratings. Understanding these can help set realistic expectations.



  • Payload and towing: Heavier loads reduce mpg, especially during acceleration and climbing grades.

  • Terrain and driving style: Stop-and-go city driving lowers mpg more than steady highway cruising; aggressive acceleration further lowers it.

  • Tire size and type: Larger or off-road tires increase rolling resistance and can reduce mpg.

  • Maintenance and fuel quality: Regular maintenance, proper air filters, and correct tire inflation improve efficiency.


Tip: If fuel economy is a priority, consider a lighter configuration, maintain proper tire pressure, and use efficient towing practices. Highway driving generally yields the best mileage for these trucks.


Summary


The 2022 Silverado 2500HD with the 6.6L Duramax diesel delivers strong towing capability with fuel economy in the low-to-mid teens in combined driving for most configurations, and higher highway efficiency for 2WD setups. Real-world mileage varies with payload, towing, and driving conditions, so refer to the exact EPA figures for your specific build and use them to estimate fuel costs.

Kevin's Auto

Kevin Bennett

Company Owner

Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.