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How many miles per gallon does a Lexus RX 350 get?

The Lexus RX 350 typically returns around 28 miles per gallon combined, with variations by drivetrain and model year. Front-wheel-drive (FWD) versions tend to achieve slightly higher overall efficiency than all-wheel-drive (AWD) variants — roughly 26 mpg city / 33 mpg highway / about 29 mpg combined for FWD, versus around 25 mpg city / 32–33 mpg highway / about 28–29 mpg combined for AWD.


These figures come from EPA estimates used in official vehicle ratings and can differ by year, trim, and equipment. The RX 350 uses a 3.5-liter V6 paired with an 8-speed automatic transmission, and real-world mileage depends on driving style, road conditions, climate, and tire choice. The numbers below summarize typical EPA ranges for recent model years.


EPA estimates by drivetrain


These EPA estimates illustrate the typical mpg separation between front-wheel drive and all-wheel drive RX 350 models in recent years.



  • RX 350 FWD: about 26 mpg city, 33 mpg highway, 29 mpg combined.

  • RX 350 AWD: about 25 mpg city, 32–33 mpg highway, 28–29 mpg combined.


Note: Actual mileage can vary by year and configuration. Always check the EPA ratings for the exact year and trim you’re considering.


Maximizing fuel economy in daily driving


Whether you’re commuting or running errands, a few practical habits can help you get closer to the EPA estimates from your RX 350.



  • Keep tires inflated to the recommended pressure; underinflated tires waste fuel.

  • Drive smoothly: gradual acceleration and gentle braking save energy.

  • Use eco/efficiency modes if equipped, and maintain steady speeds on highways.

  • Lighten the load: remove excess roof racks and unnecessary cargo.

  • Schedule regular maintenance: clean air filters, timely oil changes, and proper engine tune-ups improve efficiency.


Even with best practices, real-world mpg varies by conditions. If higher efficiency is a priority, consider the RX 350h hybrid option, which delivers greater overall fuel economy but is a different model variant.


Summary


In short, the RX 350 generally lands in the mid-to-high 20s for mpg in combined driving, with FWD models tending toward the higher end and AWD models slightly lower. For precise numbers, check the EPA ratings for the specific model year and configuration you’re evaluating, since trims and updates can shift the exact figures.

Kevin's Auto

Kevin Bennett

Company Owner

Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.