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How many miles can a Lexus RX 350 go on a tank of gas?

A typical Lexus RX 350 can travel about 430–480 miles on a full tank, depending on year, drivetrain, and driving conditions.


In this article, we break down the key numbers that determine range—tank size, fuel economy, and real-world factors—so you can estimate how far you’ll be able to go before refueling. The RX 350’s range depends on the fuel tank size and how efficiently the engine uses fuel, which varies by model year, configuration, and driving style.


Key figures for recent RX 350 models


Below are the core numbers that influence range for most gasoline versions of the RX 350 in recent years.



  • Fuel tank capacity: approximately 17.2 gallons (about 65 liters) in most RX 350 variants.

  • Typical EPA combined fuel economy: generally in the mid-20s mpg, with variations by drivetrain and year (FWD vs AWD, and engine tuning).

  • Estimated range per tank: roughly 430 to 480 miles, depending on the exact mpg and driving conditions.


Real-world mileage can vary widely. Highway cruising tends to yield higher mpg and longer range, while city driving and heavy loads shorten the distance between fills.


Hybrid RX 350h and other powertrains


For context, a hybrid version of the RX family (such as the RX 350h) uses a different powertrain combination that can improve mpg and extend range per tank, but its exact numbers depend on battery usage, driving conditions, and model year. The question here focuses on the gasoline-only RX 350, where the figures above apply as a baseline.


How driving conditions influence range


Driving conditions and behavior can swing your actual range from the baseline figures above. The factors below explain why real-world numbers differ from the theoretical range.



  1. City driving with frequent stops generally reduces mpg compared to long highway trips.

  2. Highway driving at steady speeds tends to improve mpg and extend range per tank.

  3. All-wheel drive and carrying cargo add weight and mechanical drag, which can lower mpg slightly.


To maximize range, drivers often experience better results on long highway stretches with a light load and steady speeds, while congested urban commutes will typically shorten the distance you can cover on a tank.


Summary


Across recent gasoline RX 350 models, expect a practical range of roughly 430–480 miles per tank, assuming typical highway-to-city driving patterns and a 17.2-gallon fuel tank. Real-world figures vary by year, drivetrain, and driving conditions, so use these numbers as a baseline for planning trips and fuel stops.


Bottom line: plan on about four to five hundred miles per tank for the RX 350 under normal conditions, with highway driving offering the best potential mileage and city driving reducing that range.

How far can a Lexus RX 350 go on a full tank?


570 miles
2022 Lexus RX 350 Driving Range
The 2022 Lexus RX 350 has a max range of at least 570 miles using the hybrid version. Owners of the Lexus RX 350 can expect an estimated 27 miles per gallon when driving on the highway and 20mpg around the city to make a combined 23mpg.



How many miles does a Lexus RX 350 get per gallon?


Drivers in the 2022 Lexus RX 350 will get an estimated 27 miles per gallon when driving on the highway and 20 miles per gallon around the town to make a combined 23mpg.



What is the weakness of the Lexus RX 350?


Early Lexus RX 350 releases experienced steering issues, notably power steering fluid leaks from the rack and pinion system. Not only is this a massive safety hazard – it can also be costly to repair.



How many miles can a Lexus go on a full tank?


The 2022 Lexus IS has more than 430 miles of maximum range on a single full tank of fuel. The 2022 Lexus IS has the option to use 1 of 4 available engines with their own unique fuel efficiency.


Kevin's Auto

Kevin Bennett

Company Owner

Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.