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How many miles per gallon does a 2006 Chevy Silverado 2500HD work truck get?

In short, the 2006 Silverado 2500HD work truck typically delivers about 13–15 miles per gallon (mpg) combined with the gasoline 6.0L V8 and roughly 18–19 mpg combined with the 6.6L Duramax diesel; exact numbers depend on engine choice, drivetrain, and payload.


Those figures reflect the era’s EPA estimates and common real‑world driving reports. Fuel economy varies widely with towing, payload, terrain, and maintenance, so individual results may differ. This article breaks down the mpg by configuration and provides practical guidance for maximizing efficiency.


Engine options and mpg ranges


The following ranges summarize typical mpg by engine and drivetrain configuration for the 2006 Silverado 2500HD Work Truck.



  • Gasoline engine: 6.0L V8

    • 2WD: roughly 11–13 mpg city and 16–18 mpg highway (combined ≈13–15 mpg)

    • 4WD: roughly 10–12 mpg city and 15–17 mpg highway (combined ≈12–14 mpg)



  • Diesel engine: 6.6L Duramax

    • 2WD: roughly 15–16 mpg city and 20–22 mpg highway (combined ≈18–19 mpg)

    • 4WD: roughly 14–15 mpg city and 19–21 mpg highway (combined ≈17–18 mpg)




In summary, diesel models generally deliver better highway efficiency, while gas models are more sensitive to payload and towing. The 4WD variants tend to consume more fuel than their 2WD counterparts due to extra weight and drivetrain losses.


Real-world fuel economy and influencing factors


Real‑world mpg can differ from EPA estimates depending on use case, especially with heavy towing or payload. The following factors frequently influence mileage on a 2006 Silverado 2500HD Work Truck.



  • Towing and payload: Heavier loads reduce mpg significantly, especially in city driving or on grades.

  • Terrain and driving style: Lots of hills, aggressive acceleration, or sustained high speeds lower efficiency.

  • Maintenance and condition: Proper tire pressure, air filters, ignition timing, and fuel system cleanliness can shift numbers.

  • Drivetrain configuration: 4x4 drivetrains and larger fuel systems typically result in lower mpg than 2WD setups.

  • Vehicle age and wear: With time, engines and transmissions may become less efficient if not serviced.


Understanding these factors helps interpret the mpg range for any given truck and informs decisions about towing needs, routes, and maintenance schedules.


Tips to maximize fuel economy



  1. Keep tires inflated to the manufacturer’s recommended pressure; underinflation increases rolling resistance.

  2. Plan ahead to minimize idling and combine trips to reduce wasted fuel.

  3. Avoid excessive speeds; driving at moderate speeds improves highway mileage.

  4. Lighten payload when possible; remove unnecessary equipment to reduce weight.

  5. Schedule regular maintenance: air filters, fuel injectors, and spark plugs in good condition help efficiency.

  6. Use cruise control on flat, open highways when appropriate to maintain steady speed.


Implementing these practices can yield noticeable gains, especially on long highway drives or when without heavy towing.


Summary


The 2006 Chevy Silverado 2500HD Work Truck offers two primary engine choices with distinct mpg profiles. Gasoline 6.0L V8 models typically fall in the mid-teens mpg combined, with 2WD slightly higher than 4WD variants. Duramax diesel models generally deliver better highway efficiency and higher combined mileage, particularly in 2WD configurations. Real-world mileage depends heavily on towing, payload, terrain, and maintenance. For owners planning heavy towing or daily highway trips, considering the diesel option or optimizing load and driving habits can help maximize efficiency.

Kevin's Auto

Kevin Bennett

Company Owner

Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.