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How many miles per gallon does a E350 get?

The number of miles per gallon (MPG) a Mercedes-Benz E‑Class E350 delivers depends on the model year, engine and drivetrain. In general, modern E350s hover in the mid‑20s mpg combined, with highway driving returning higher figures and city driving lower. For precise figures, refer to the EPA window sticker for the exact year and configuration.


What factors most affect the E350’s fuel economy?


Several elements determine an E350’s MPG. Understanding these helps set expectations and identify ways to improve efficiency.



  • Engine type and displacement: older E350s used a 3.5L V6, while newer models rely on smaller turbocharged engines that often improve highway efficiency.

  • Drivetrain: rear‑wheel drive (RWD) versus all‑wheel drive (4MATIC) typically changes mpg, usually with 4MATIC offering lower fuel economy due to added drivetrain weight and friction.

  • Transmission: the number of gears and shifting behavior affect efficiency, with modern 9‑speed automatics commonly helping to optimize fuel use.

  • Vehicle weight and aerodynamics: larger sedans like the E‑Class carry more weight and have different drag characteristics than compact cars, impacting mpg.

  • Maintenance and condition: proper tire inflation, clean air filters, spark plugs, and general mechanical health influence real‑world mileage.

  • Driving style and conditions: aggressive acceleration, high speeds, and frequent stop‑and‑go driving reduce mpg versus steady highway cruising.


These factors mean actual MPG can vary significantly from the official ratings depending on how the car is used and maintained.


MPG by era and engine configuration


Older E350s with the 3.5L V6 (rough estimates)


Past E350 models that used the 3.5-liter V6 generally posted lower city mpg and mid‑range highway efficiency, with overall figures typically in the low 20s mpg combined. All‑wheel-drive versions tended to be on the lower end due to added drivetrain weight.



  • City: roughly 17–19 mpg

  • Highway: roughly 25–29 mpg

  • Combined: roughly 21–23 mpg


Keep in mind that variations between model years, tires and maintenance can shift these numbers by a few mpg in either direction.


Newer E350s with a turbocharged 2.0L four (rough estimates)


More recent E350 configurations use a smaller, turbocharged engine designed for better highway efficiency, which typically yields higher overall mpg than the older V6 models.



  • City: roughly 23–25 mpg

  • Highway: roughly 32–34 mpg

  • Combined: roughly 27–29 mpg


All‑wheel drive versions may see a modest drop in overall mpg compared with RWD variants due to drivetrain losses.


How to maximize the E350’s fuel economy


If you’re aiming to squeeze every mile out of a tank, these practical steps can help improve real‑world mpg without sacrificing safety or comfort.



  1. Maintain proper tire pressure: under‑inflated tires reduce efficiency and increase wear.

  2. Adopt smoother driving habits: gradual acceleration, steady speeds, and timely use of cruise control when appropriate.

  3. Follow regular maintenance: replace air filters, spark plugs, and oxygen sensors as recommended; use the correct fuel and keep the engine tuned.

  4. Plan trips to minimize cold starts: combine short trips into longer ones and avoid unnecessary idling.

  5. Use Eco/efficient driving modes if equipped and appropriate tires with low rolling resistance when available.


These measures can help you approach or exceed the typical MPG range for your specific E350 configuration.


EPA estimates vs. real‑world mileage


EPA ratings are based on standardized tests that do not always reflect typical driving. Real‑world mileage often varies due to terrain, climate, load, driving style, and maintenance. For the exact figures of your specific vehicle, check the official EPA rating for your model year and drivetrain, or review the window sticker when purchasing used.


Summary


In short, the E‑Class E350’s MPG depends on year, engine and drivetrain. Roughly speaking, older V6 versions tend to deliver in the low 20s combined, while newer turbocharged configurations generally reach the upper 20s to around 30 mpg combined, with highway figures higher than city figures. For precise numbers, consult the EPA ratings for the exact model year and drive configuration, and consider practical adjustments to driving and maintenance to maximize efficiency.

Which car gets 70 MPG?


Several hybrid and diesel cars can achieve around 70 mpg, though it's often an official rating and can vary in real-world driving. Examples include the Vauxhall Corsa with a 1.5-litre turbo diesel engine, which can get up to 70.6 mpg, and various hybrid models, including some versions of the Hyundai Elantra Hybrid and Toyota Prius, which can reach this level under ideal conditions.
 
Examples of cars with around 70 mpg

  • Vauxhall Corsa (1.5-litre turbo diesel): Can achieve up to 70.6 mpg, making it one of the most fuel-efficient diesel cars available. 
  • Hyundai Elantra Hybrid: Early models were advertised with a claimed 70 mpg combined fuel economy. 
  • Toyota Prius: Various models can get close to 70 mpg, especially older non-plug-in hybrids which are cheaper on the used market. Plug-in hybrid versions can also run on electric power for short distances. 
  • Hyundai Ioniq Hybrid: Can achieve around 59 mpg combined. 

Important considerations
  • Official vs. real-world MPG: The 70 mpg figure is often an official rating that is achieved under specific testing conditions, and your real-world mileage may be lower or higher depending on your driving habits, the vehicle's condition, and road conditions. 
  • Hybrid vs. diesel: Both hybrid and diesel cars can achieve high MPG, but hybrids have the added benefit of electric-only driving for short distances, while some diesels can have higher upfront costs but offer impressive fuel economy on long-distance journeys. 
  • Age and model: Some of the models with the highest MPG ratings are older, so be sure to research specific model years when shopping. 
  • Type of driving: While hybrids and diesels can be very efficient, their fuel economy can vary significantly depending on whether you are driving in the city or on the highway. 



How many miles per gallon does the E 350 get?


This comes from the estimated mileage numbers of the base E 350, which is expected to return 23 city mpg and 31 highway mpg, which makes for a combined 27mpg. In comparison, the 4MATIC® model is expected to get 21 city miles per gallon and 29 highway mpg, making for a combined 25mpg.



Is E350 a V6 or V8?


V6
A 268-hp, 3.5-liter gasoline V6 engine powers the E350.



What is the gas mileage on a 2010 Ford E350 Super Duty?


All trim levels of the 2010 E350 Super Duty Passenger get 13 MPG, with 11 MPG in the city and 15 MPG on the highway.


Kevin's Auto

Kevin Bennett

Company Owner

Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.