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What is the gas mileage on a 2006 Chevy Express 2500?

In brief, a 2006 Chevy Express 2500 typically achieves fuel economy in the mid-teens, with highway running often higher than city driving. The exact mileage depends on engine choice, payload, and driving conditions.


Overview


The Chevrolet Express 2500 is a full-size van offered with multiple gasoline engine options and rear-wheel drive. Weight, cargo load, the chosen engine, and maintenance all significantly influence real-world fuel economy. For older vans like the 2006 model year, EPA estimates provide a baseline, but drivers may see a range that reflects their specific configuration and usage.


Engine options and EPA estimates


The following are common engine configurations for the 2006 Express 2500 and their approximate EPA fuel economy ranges. These figures assume gasoline engines paired with the typical automatic transmission and rear-wheel drive; actual numbers can vary with load and driving style.



  • 4.3L V6 (Vortec 4300) with a 4-speed automatic, rear-wheel drive: about 14 mpg city / 19–20 mpg highway; roughly 16–17 mpg combined.

  • 4.8L V8: about 13–14 mpg city / 18–19 mpg highway; roughly 15–16 mpg combined.

  • 5.3L V8: about 14–15 mpg city / 19–20 mpg highway; roughly 17–18 mpg combined.

  • 6.0L V8: about 12–13 mpg city / 17–18 mpg highway; roughly 14–15 mpg combined.


These ranges reflect EPA-era estimates and typical configurations. Real-world mileage will vary based on cargo weight, tire condition and size, aerodynamic factors, and maintenance history.


Real-world considerations and tips


For drivers looking to maximize fuel economy in a 2006 Express 2500, practical steps include keeping tires inflated to the recommended pressure, removing unnecessary cargo, performing regular maintenance (air filter, spark plugs, oil changes), and adopting smooth driving habits such as gradual acceleration and steady cruising. Our guidance aims to help you understand the baseline and optimize performance within the vehicle’s inherently large footprint and payload capacity.


Summary


In summary, the 2006 Chevy Express 2500 offers a range of gas mileage figures largely driven by engine choice. Expect roughly 12–15 mpg in city driving and 17–20 mpg on highways, with combined averages typically in the mid-teens. The 4.3L V6 usually yields the best highway efficiency among the gas options, while the larger V8s consume more fuel under similar conditions. Always refer to your specific vehicle’s configuration for the most accurate estimate.

Kevin's Auto

Kevin Bennett

Company Owner

Kevin Bennet is the founder and owner of Kevin's Autos, a leading automotive service provider in Australia. With a deep commitment to customer satisfaction and years of industry expertise, Kevin uses his blog to answer the most common questions posed by his customers. From maintenance tips to troubleshooting advice, Kevin's articles are designed to empower drivers with the knowledge they need to keep their vehicles running smoothly and safely.